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GeneE
10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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OTP
orthopedia homeobox
Chromosome 5 · 5q14.1
NCBI Gene: 23440Ensembl: ENSG00000171540.8HGNC: HGNC:8518UniProt: Q5XKR4
13PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Transcription Factor
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
RNA polymerase II transcription regulatory region sequence-specific DNA bindingDNA-binding transcription repressor activity, RNA polymerase II-specificprotein bindingnegative regulation of transcription by RNA polymerase IIMODYobesity due to melanocortin 4 receptor deficiencydiabetes mellitusshort stature due to primary acid-labile subunit deficiency
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

orthopedia homeobox

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
MODYOpen Targets
0.07Suggestive
obesity due to melanocortin 4 receptor deficiencyOpen Targets
0.07Suggestive
diabetes mellitusOpen Targets
0.07Suggestive
short stature due to primary acid-labile subunit deficiencyOpen Targets
0.07Suggestive
hypoinsulinemic hypoglycemia and body hemihypertrophyOpen Targets
0.06Suggestive
type 2 diabetes mellitusOpen Targets
0.06Suggestive
central nervous system cancerOpen Targets
0.06Suggestive
obesityOpen Targets
0.06Suggestive
obesity due to leptin receptor gene deficiencyOpen Targets
0.05Suggestive
obesity due to prohormone convertase I deficiencyOpen Targets
0.05Suggestive
neoplasmOpen Targets
0.05Suggestive
carcinoid tumorOpen Targets
0.05Suggestive
hyperinsulinemic hypoglycemia, familial, 1Open Targets
0.05Suggestive
Hyperandrogenism due to cortisone reductase deficiencyOpen Targets
0.05Suggestive
obesity due to pro-opiomelanocortin deficiencyOpen Targets
0.05Suggestive
hyperinsulinemic hypoglycemia, familial, 2Open Targets
0.05Suggestive
lung diseaseOpen Targets
0.05Suggestive
severe early-onset obesity-insulin resistance syndrome due to SH2B1 deficiencyOpen Targets
0.05Suggestive
obesity and hypopigmentationOpen Targets
0.04Suggestive
thyroid hormone resistance, generalized, autosomal recessiveOpen Targets
0.04Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
LHX4Shared pathway100%LHX5Shared pathway100%NIF3L1Shared pathway100%LHX9Shared pathway100%POU3F2Protein interaction79%OXTProtein interaction74%
Tissue Expression6 tissues
Brain
100%
Liver
0%
Ovary
0%
Heart
0%
Lung
0%
Bone Marrow
0%
Gene Interaction Network
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OTPLHX4LHX5NIF3L1LHX9POU3F2OXT
PROTEIN STRUCTURE
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AlphaFoldAI-predicted · UniProt Q5XKR4
View on AlphaFold ↗
Constraintⓘ
LOEUFⓘ
0.73LoF Tolerant
pLIⓘ
0.59Intermediate
Observed/Expected LoF0.35 [0.18–0.73]
RankingsWhere OTP stands among ~20K protein-coding genes
  • #16,246of 20,598
    Most Researched13
  • #5,634of 17,882
    Most Constrained (LOEUF)0.73
Genes detectedOTP
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
[Impactor-fixator].
PMID: 609444
Ortop Travmatol Protez · 1977
1.00
2
[Achillodynia].
PMID: 13407967
Ortop Travmatol Protez · 1956
0.90
3
[Rashp-hemisphere].
PMID: 13613736
Ortop Travmatol Protez · 1958
0.80
4
[Goniometer].
PMID: 7099606
Ortop Travmatol Protez · 1982
0.70
5
[ARTHROSIS DEFORMANS].
PMID: 14250241
Ortop Travmatol Protez · 1964
0.60