Based on limited published evidence, PABPC4L is a cytoplasmic poly(A) binding protein that may bind RNA, particularly mRNA 3'-UTR and poly(U) sequences. It localizes to the nucleus and cytoplasm, and associates with cytoplasmic stress granules and ribonucleoprotein complexes. A stop-gain variant (p.R271X) in PABPC4L was identified in familial atypical parkinsonism, causing cellular mislocalization and impaired stress granule association 1. Additionally, rare deletions spanning PABPC4L showed modest enrichment in treatment-resistant depression 2, though these associations did not survive genome-wide correction.