PANX2 is a heptameric ion channel that functions as a large-pore, ATP-permeable membrane channel 1. Structurally, PANX2 exhibits anion selectivity through a ring of seven arginine residues at its extracellular entrance, which acts as a molecular filter 2. The channel facilitates ATP release and ion transport across cell membranes in response to physiological and pathological stimuli 3. PANX2 mediates multiple physiological processes including skin homeostasis, neuronal development, and apoptosis regulation 2. While less extensively characterized than PANX1, PANX2 exhibits more intracellular localization compared to other pannexins 4. The channel participates in inflammatory responses and energy production 1. Clinically, PANX2 dysfunction is implicated in pathological conditions including ischemic brain injury and gliomas 1. In brain low-grade gliomas, elevated PANX2 expression correlates with improved overall survival and involves neuroactive ligand-receptor interaction and calcium signaling pathways 3. Conversely, in colorectal cancer, PANX2 overexpression promotes malignant transformation and 5-fluorouracil resistance through PI3K-AKT signaling 5. These contrasting roles suggest PANX2 may represent a context-dependent therapeutic target, with channel inhibition potentially beneficial in certain malignancies while maintaining physiological functions in others.