PBDC1 (polysaccharide biosynthesis domain containing 1) is an X-linked gene with predicted roles in protein folding and chaperone function based on GO annotations for protein binding and de novo cotranslational protein folding. The primary known association with PBDC1 involves neurodevelopment; it resides within a 1.7 Mb deletion on chromosome X that segregates with autism spectrum disorder (ASD) in a multiplex family, though ZDHHC15 appears to be the primary candidate gene in this region 1. PBDC1 was identified as one of multiple genes deleted in three family members presenting with ASD and abnormal sensory profiles, with normal cognitive abilities. Limited functional characterization is available; PBDC1 has been detected as a protein showing altered expression in pancreatic beta-cells exposed to DDT toxicity 2, suggesting potential involvement in cellular stress responses, though this appears incidental to toxicology screening rather than reflective of primary gene function. The gene's precise molecular mechanism and clinical significance remain incompletely defined. Further research is needed to establish PBDC1's independent contribution to disease pathology versus its role as part of larger genomic deletions affecting neurodevelopment.