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GeneE
1 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
PCNX3
pecanex 3
Chromosome 11 Β· 11q13.1
NCBI Gene: 399909Ensembl: ENSG00000197136.6HGNC: HGNC:18760UniProt: Q9H6A9
27PubMed Papers
20Diseases
0Drugs
1Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
protein bindingmembraneMoyamoya diseasecoronary artery diseaseacneessential hypertension
✦AI Summary

Based on limited published evidence, PCNX3 is a protein with demonstrated binding capability. In lung cancer, PCNX functions as a competitive endogenous RNA (ceRNA) that regulates S-phase kinase associated protein 2 (Skp2) through miRNA-dependent mechanisms involving miR-26, miR-182, miR-340, and miR-506 1. PCNX3's 3' UTR promotes lung cancer cell growth, proliferation, and cell cycle progression while suppressing apoptosis, suggesting an oncogenic role in non-small cell lung cancer 1.

Sources cited
1
PCNX functions as a ceRNA of Skp2 in lung cancer, regulating cell growth and proliferation through miRNA-dependent mechanisms
PMID: 28789966
⚠Limited data available β€” This gene has 1 indexed publication. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
Moyamoya diseaseOpen Targets
0.26Weak
coronary artery diseaseOpen Targets
0.06Suggestive
acneOpen Targets
0.05Suggestive
essential hypertensionOpen Targets
0.04Suggestive
cerebrovascular disorderOpen Targets
0.04Suggestive
hypertensionOpen Targets
0.04Suggestive
major depressive disorderOpen Targets
0.04Suggestive
schizophreniaOpen Targets
0.03Suggestive
alcohol drinkingOpen Targets
0.03Suggestive
Epidermal Inclusion CystOpen Targets
0.02Suggestive
septic shockOpen Targets
0.02Suggestive
angina pectorisOpen Targets
0.02Suggestive
complicationOpen Targets
0.02Suggestive
medical procedureOpen Targets
0.02Suggestive
cancerOpen Targets
0.01Suggestive
goutOpen Targets
0.01Suggestive
hyperuricemiaOpen Targets
0.00Suggestive
psoriatic arthritisOpen Targets
0.00Suggestive
neoplasmOpen Targets
0.00Suggestive
colon adenomaOpen Targets
0.00Suggestive
Pathogenic Variants1
NM_032223.4(PCNX3):c.229_230del (p.Val77fs)Likely pathogenic
Moyamoya angiopathy
β˜†β˜†β˜†β˜†β†’ Residue 77
View on ClinVar β†—
Related Genes
INTS1Protein interaction79%ATP13A1Protein interaction79%
Tissue Expression6 tissues
Bone Marrow
100%
Lung
89%
Liver
68%
Ovary
68%
Brain
37%
Heart
35%
Gene Interaction Network
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PCNX3INTS1ATP13A1
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt Q9H6A9
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
0.40Moderately Constrained
pLIβ“˜
1.00Intolerant
Observed/Expected LoF0.32 [0.26–0.40]
RankingsWhere PCNX3 stands among ~20K protein-coding genes
  • #12,633of 20,598
    Most Researched27
  • #5,289of 5,498
    Most Pathogenic Variants1
  • #1,957of 17,882
    Most Constrained (LOEUF)0.40 Β· top quartile
Genes detectedPCNX3
Sources retrieved1 papers
Response timeβ€”
πŸ“„ Sources
1
1
Pecanex functions as a competitive endogenous RNA of S-phase kinase associated protein 2 in lung cancer.
PMID: 28789966
Cancer Lett Β· 2017
1.00