PDE10A (phosphodiesterase 10A) is a cyclic nucleotide phosphodiesterase that regulates intracellular signaling by hydrolyzing both cAMP and cGMP, with preferential catalytic efficiency for cAMP 1234. PDE10A plays a critical role in regulating cyclic nucleotide levels within the striatum, a brain region controlling movement and cognition 4. The enzyme modulates signal transduction pathways including cAMP/PKA and cGMP/PKG signaling 5. Beyond neurological functions, PDE10A inhibition suppresses tumor cell growth and, notably, protects against doxorubicin-induced cardiotoxicity by antagonizing cardiomyocyte death through enhanced cGMP/PKG signaling and attenuating FoxO3-mediated atrophy 5. In humans, PDE10A variants are associated with complex hyperkinetic movement disorders presenting with chorea as a predominant feature in affected children 6. Additionally, PDE10A genetic variants show evidence of natural selection in the Bajau people (Sea Nomads), where they contribute to increased spleen size and enhanced hypoxia tolerance for breath-hold diving 7. PDE10A mutations are implicated in infantile-onset dyskinesia and autosomal dominant striatal degeneration, emphasizing its critical role in striatal motor control.