PDE6G encodes the gamma subunit of the cGMP-phosphodiesterase 6 complex, a critical effector in vertebrate photoreceptor phototransduction 1. The PDE6 complex, composed of alpha, beta, and two gamma subunits, plays a central role in rod and cone phototransduction by hydrolyzing cGMP in response to photons, thereby closing cGMP-gated ion channels and hyperpolarizing photoreceptor cells to transduce visual signals 2. PDE6G maintains intracellular cGMP levels essential for photoreceptor function and visual perception 2. Pathogenic variants in PDE6G cause autosomal recessive retinitis pigmentosa (AR-RP), accounting for 2-5% of all RP cases, with mutations in PDE6G associated with early-onset disease 32. Complex heterozygous mutations can result in severe early-onset RP presenting with high hyperopia, astigmatism, and characteristic bone spicule-type pigment deposits 4. Beyond inherited retinal disease, PDE6G has been identified as a hub gene correlated with diabetic retinopathy pathogenesis 5, and genome-wide association studies identified PDE6G-containing loci associated with strabismus risk 6. These findings establish PDE6G as a critical phototransduction protein with significant clinical relevance to multiple retinal disorders.