PDGFC (platelet-derived growth factor C) is a potent growth factor and chemoattractant essential for embryonic development and tissue homeostasis. Functionally, PDGFC acts as a mitogen for mesenchymal cells and regulates cell proliferation, migration, and survival through PDGF receptor binding and downstream signaling cascades including ERK1/2 and PI3K/Akt pathways 1. During development, PDGFC is critical for craniofacial skeleton formation and palate development, with roles in Meckel's cartilage-mediated mandibular ossification 2. PDGFC promotes wound healing across inflammatory, proliferative, and remodeling phases, and facilitates angiogenesis and fibrotic processes involving fibroblast-to-myofibroblast transformation 3. Diseases involving PDGFC dysregulation include radiation proctopathy, where PDGFC upregulation promotes inflammation and fibrosis through PDGFR and CXCR4 signaling 3. In cancer, PDGFC expression correlates with poor prognosis in gastric and pancreatic cancers, promoting fibrotic tumor microenvironment and immunosuppression by recruiting myeloid-derived suppressor cells via CAF-mediated chemokine production 4. PDGFC regulates pancreatic cancer progression through SREBP1-mediated lipid metabolism 5. PDGFC is expressed by tumor-promoting macrophages in cardiac myxoma 6 and shows inverse correlation with lymphocyte infiltration in thyroid carcinoma 7. Clinically, PDGFR inhibition (crenolanib) and PDGFRα/β blockade represent therapeutic strategies for radiation proctopathy and fibrotic cancers respectively 34.