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GeneE
10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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PGP
phosphoglycolate phosphatase
Chromosome 16 · 16p13.3
NCBI Gene: 283871Ensembl: ENSG00000184207.9HGNC: HGNC:8909UniProt: A6NDG6
47PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
negative regulation of gluconeogenesissn-glycerol 3-phosphatase activityglycerol biosynthetic processglycerophospholipid metabolic processneurodegenerative diseaselysosomal storage diseaseAbnormality of the skeletal systemneoplasm
✦AI Summary

Insufficient information provided. The PubMed abstracts submitted discuss P-glycoprotein (Pgp/MDR1), an ATP-binding cassette transporter involved in drug efflux and multidrug resistance, not phosphoglycolate phosphatase (PGP). Additionally, one abstract describes the angular gyrus brain region (also abbreviated PGp), which is unrelated to the gene in question. Based on the provided abstracts, no factual claims about phosphoglycolate phosphatase function, mechanism, disease relevance, or clinical significance can be supported. The UniProt summary indicates PGP is a glycerol-3-phosphate phosphatase regulating cellular glycerol-3-phosphate levels in glucose, lipid, and energy metabolism, with additional 2-phosphoglycolate and tyrosine-protein phosphatase activities [source: UniProt, not from provided PubMed abstracts]. However, per instructions, claims must be grounded in the provided abstracts, which do not contain relevant information about phosphoglycolate phosphatase. To provide an accurate gene function summary for phosphoglycolate phosphatase, abstracts specifically addressing this enzyme's biochemistry, regulation, structural properties, and disease associations would be required.

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
neurodegenerative diseaseOpen Targets
0.50Moderate
lysosomal storage diseaseOpen Targets
0.35Weak
Abnormality of the skeletal systemOpen Targets
0.16Weak
neoplasmOpen Targets
0.12Weak
cancerOpen Targets
0.12Weak
Alzheimer diseaseOpen Targets
0.10Weak
acute lymphoblastic leukemiaOpen Targets
0.10Suggestive
systemic lupus erythematosusOpen Targets
0.10Suggestive
colorectal carcinomaOpen Targets
0.09Suggestive
breast cancerOpen Targets
0.09Suggestive
hepatocellular carcinomaOpen Targets
0.09Suggestive
gliomaOpen Targets
0.09Suggestive
Parkinson diseaseOpen Targets
0.09Suggestive
fetal growth restrictionOpen Targets
0.08Suggestive
diabetes mellitusOpen Targets
0.08Suggestive
acute myeloid leukemiaOpen Targets
0.07Suggestive
Mobius syndromeOpen Targets
0.07Suggestive
chronic myelogenous leukemiaOpen Targets
0.06Suggestive
triple-negative breast cancerOpen Targets
0.06Suggestive
osteosarcomaOpen Targets
0.06Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
GRHPRProtein interaction93%HAO2Protein interaction93%HAO1Protein interaction93%HAGHProtein interaction75%MAPDAShared pathway33%CLYBLShared pathway25%
Tissue Expression6 tissues
Heart
100%
Bone Marrow
69%
Lung
66%
Brain
66%
Liver
66%
Ovary
27%
Gene Interaction Network
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PGPGRHPRHAO2HAO1HAGHMAPDACLYBL
PROTEIN STRUCTURE
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AlphaFoldAI-predicted · UniProt A6NDG6
View on AlphaFold ↗
Constraintⓘ
LOEUFⓘ
1.11LoF Tolerant
pLIⓘ
0.01Tolerant
Observed/Expected LoF0.64 [0.38–1.11]
RankingsWhere PGP stands among ~20K protein-coding genes
  • #9,253of 20,598
    Most Researched47
  • #11,353of 17,882
    Most Constrained (LOEUF)1.11
Genes detectedPGP
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
Herbal modulation of P-glycoprotein.
PMID: 15072439
Drug Metab Rev · 2004
1.00
2
Architecture and connectivity of the human angular gyrus and of its homolog region in the macaque brain.
PMID: 35695934
Brain Struct Funct · 2023
0.90
3
Variable expression of CYP and Pgp genes in the human small intestine.
PMID: 12795646
Eur J Clin Invest · 2003
0.80
4
Cardiovascular Ion Channel Inhibitor Drug-Drug Interactions with P-glycoprotein.
PMID: 28028729
AAPS J · 2017
0.70
5
Identification and characterization of the human Pgp-1 glycoprotein.
PMID: 3519447
Immunogenetics · 1986
0.60