PHACTR2 (phosphatase and actin regulator 2) is located on chromosome 6 and functions in protein binding and actin cytoskeleton organization, with localization to plasma membrane and platelet alpha granule membrane. The gene shows partial imprinting with skewed allelic expression in a parent-specific manner in human placenta, suggesting genomic regulation similar to its neighbor PLAGL1 1. PHACTR2 genetic variants have been investigated as potential biomarkers for various diseases. The rs9390123 polymorphism was identified as part of a nine-protein biomarker combination for assessing systemic lupus erythematosus disease exacerbation 2, though this same variant showed no association with non-small-cell lung cancer risk in Chinese populations 3. Another variant (rs11155313) demonstrated association with Parkinson's disease risk across multiple populations with combined odds ratio of 1.30 4. The PHACTR2-AS1 antisense RNA plays a crucial regulatory role, functioning as a tumor suppressor by maintaining ribosomal DNA stability through H3K9 methylation, with its downregulation promoting breast cancer growth and metastasis 5. However, PHACTR2-AS1 paradoxically promotes tongue squamous cell carcinoma metastasis through miR-137/Snail pathway regulation 6. Additionally, NFIB::PHACTR2 fusion has been identified as a novel translocation in adenoid cystic carcinoma 7.