PLCL1 (phospholipase C like 1) is an inactive phospholipase C family member that participates in intracellular signaling cascades despite lacking catalytic PLC activity 1. The protein functions as a tumor suppressor in multiple cancer types, including renal cell carcinoma where it inhibits tumor progression through AMPK/mTOR-mediated autophagy activation and regulation of lipid metabolism 23. In clear cell renal cell carcinoma, PLCL1 decreases lipid accumulation via UCP1-mediated lipid browning and promotes tumor apoptosis through p38 phosphorylation 3. PLCL1 also acts as a metastasis suppressor in neuroblastoma, with low expression associated with metastatic disease and poor survival 4. In diabetic kidney disease, DOT1L protects against podocyte injury by upregulating PLCL1 expression through H3K79me2 methylation at its promoter, improving abnormal fatty acid metabolism 1. However, PLCL1 can promote inflammatory responses in rheumatoid arthritis fibroblast-like synoviocytes through NLRP3 inflammasome regulation 5. The protein has been identified as a GWAS factor in schizophrenia organoids and shows associations with cocaine use disorder, suggesting broader roles in neuropsychiatric conditions 67.