PLGRKT (plasminogen receptor with a C-terminal lysine) is a unique transmembrane plasminogen receptor that plays crucial roles in plasminogen activation and cellular regulation. The protein functions as a cell surface receptor that binds plasminogen through its C-terminal lysine domain, promoting plasminogen activation to plasmin 1. PLGRKT physically associates with the urokinase receptor (uPAR) to enhance this plasmin activation process 1. Beyond fibrinolysis, PLGRKT demonstrates diverse physiological functions including regulation of spermatogonial stem cell maintenance through interaction with BMI1 and modulation of oxidative stress pathways 2. The receptor is essential for lactation and species survival through both plasminogen-dependent and independent mechanisms 1. In disease contexts, PLGRKT shows significant involvement in cancer progression, particularly in pancreatic ductal adenocarcinoma where plasminogen receptor deficiency suppresses tumor growth and metastasis 3. The receptor also mediates lipoprotein(a) uptake in hepatoma cells, with the internalized apolipoprotein(a) component being recycled back to cellular media 4. Additionally, PLGRKT has been identified as a novel genetic locus associated with polycystic ovary syndrome risk 5, suggesting broader roles in metabolic and reproductive disorders.