Plasmolipin (PLLP) is a main component of the myelin sheath that plays a crucial role in myelin membrane biogenesis and myelination 1. The protein localizes to and recycles between the plasma membrane and Golgi complex, where it forms oligomers through fluorescence resonance energy transfer interactions 1. PLLP functions by inducing liquid-ordered membrane domains in the Golgi complex, which serve as potential myelin membrane precursor sites 1. The protein blocks Golgi-to-plasma membrane transport of certain secretory proteins, suggesting its role in organizing specialized membrane domains 1. PLLP interacts with ganglioside GM1 in lipid rafts, inducing structural changes in its extracellular loops that propagate conformational signals through the plasma membrane via cholesterol molecules, ultimately reaching the intracellular domain 2. In disease contexts, PLLP has been implicated in various pathological conditions including cancer, neurological disorders, and type 2 diabetes 3. Additionally, PLLP knockout in endothelial cells enhances cell survival under hypoxic conditions by promoting AKT and ERK1/2 phosphorylation, increasing proliferation, metabolism, and angiogenesis 4. Genome-wide association studies have also identified PLLP variants associated with hematuria 5.