PLSCR5 (phospholipid scramblase family member 5) encodes a phospholipid scramblase that mediates plasma membrane phospholipid asymmetry through phosphatidylserine externalization 1. In auditory function, PLSCR5 is a downstream transcriptional target of POU4F3 and is essential for maintaining cochlear hair cell stereocilia integrity and structural homeostasis 1. PLSCR5-deficient mice develop progressive hearing loss characterized by stereocilia degeneration and hair cell loss, with particular importance for inner hair cell function 1. Beyond hearing, PLSCR5 has been identified as a candidate gene in genome-wide association studies for fatty acid composition in cattle 2 and for innate immune resistance to Toxoplasma gondii infection in sheep 3, suggesting broader roles in metabolic and immunological processes. Clinically, rare heterozygous variants in PLSCR5 have been identified in families with early-onset bipolar disorder and comorbid anxiety disorders, potentially implicating dysfunction in CREB-regulated intracellular signaling pathways 4. These findings collectively indicate PLSCR5 functions in maintaining membrane dynamics critical for sensory and neurological function, with disease associations including deafness (DFNA15) and psychiatric disorders.