2 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
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22PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingneoplasmchildhood supratentorial ependymomachildhood leukemiacancer
Based on limited published evidence, PNMA6A is a protein-binding protein located on chromosome X. UniProt annotations describe it as having protein binding capability. Recent studies have identified PNMA6A as part of an ac4C-related gene signature associated with melanoma progression and immunotherapy response 1, and as a recurrently mutated gene in WHO grade 1 meningiomas, with variants detected in 22% of cases 2. However, the specific molecular function and biological role of PNMA6A remain poorly characterized in current literature.
1
PNMA6A was identified as part of an ac4C-related gene signature associated with melanoma progression, immunotherapy response, and overall survival prediction
PMID: 400508212
PNMA6A mutations were detected in 22% of WHO grade 1 meningiomas, making it a recurrently mutated gene in this tumor type
PMID: 34868937⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
childhood supratentorial ependymomaOpen Targets
childhood leukemiaOpen Targets
acute lymphoblastic leukemiaOpen Targets
acute myeloid leukemiaOpen Targets
Burkitts lymphomaOpen Targets
Alzheimer diseaseOpen Targets
chronic myelogenous leukemiaOpen Targets
colorectal cancerOpen Targets
retinitis pigmentosa 1Open Targets
X-linked hyper-IgM syndromeOpen Targets
bladder transitional cell carcinomaOpen Targets
type 2 diabetes mellitusOpen Targets
nasopharyngeal carcinomaOpen Targets
No pathogenic variants reported on ClinVar for this gene.