Periplakin (PPL) is a plakin family member that functions as a structural component of the cornified envelope in keratinocytes, linking the cornified envelope to desmosomes and intermediate filaments 1. PPL plays a critical role in cellular adhesion complexes and cytoskeletal integrity 1. The protein exhibits cadherin-binding activity and responds to mechanical stimuli, contributing to intermediate filament organization and wound healing processes. In cancer biology, PPL has emerged as a significant prognostic biomarker. In ovarian cancer, PPL expression is substantially elevated compared to normal tissues, and high PPL expression correlates strongly with poor survival outcomes 1. Functionally, PPL participates in key signaling pathways including Wnt and MAPK pathways, and associates with hub genes involved in cell adhesion and migration (LAMC2, PXN, LAMA3, LAMB3, ITGA3, TLN1, ACTN4, ITGB4) 1. Additionally, PPL expression inversely correlates with infiltration of CD4+ T cells, macrophages, neutrophils, and dendritic cells, suggesting immunomodulatory functions relevant to immunotherapy response 1. These findings identify PPL as an unfavorable prognostic biomarker candidate that may guide treatment selection and predict immunotherapy efficacy in ovarian cancer patients.