PRDX2 is a thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides, protecting cells against oxidative stress 1. As a 2-Cys enzyme, PRDX2 functions as an effective reactive oxygen species (ROS) scavenger and hydrogen peroxide detoxifier, defending cells from oxidative damage 1. Beyond antioxidant activity, PRDX2 participates in cellular signaling cascades, including VEGFR2 signaling and inflammatory responses, by regulating intracellular H₂O₂ concentrations and protein interactions 2. PRDX2 exhibits dual roles in cancer depending on developmental stage. While typically acting as an onco-suppressor in early cancer stages, PRDX2 overexpression is associated with colorectal, cervical, breast, and prostate cancers 1. In gastric cancer specifically, PRDX2 promotes progression by stabilizing pyruvate kinase M2 (PKM2) and activating STAT3 signaling, forming a positive feedback loop 3. Conversely, PRDX2 inhibition by natural compounds (Celastrol, Triptolide, Ainsliadimer A) increases ROS levels, triggering apoptosis through endoplasmic reticulum stress and mitochondrial dysfunction 456. Clinically, elevated PRDX2 correlates with poor prognosis in gastric cancer 3. Direct PRDX2 inhibition represents a promising therapeutic strategy for multiple cancers, with several natural product derivatives under investigation 45.