Based on limited published evidence, PRPF38B is a pre-mRNA processing factor predicted to function in pre-mRNA splicing. UniProt annotations indicate it has RNA binding capacity and localizes to the precatalytic spliceosome, suggesting a role in early spliceosome assembly or regulation. In cancer research, PRPF38B was identified as a splicing factor potentially correlated with prognosis-related alternative splicing events in ovarian carcinoma 1, though its specific molecular mechanism remains unclear.