PRR5-ARHGAP8 is a readthrough transcript encoding a fusion protein combining PRR5 and ARHGAP8 1. PRR5 functions as a subunit of mTORC2, a serine/threonine kinase involved in food intake regulation, while ARHGAP8 belongs to the RhoGAP family, mediating cross-talk between Rho GTPases and other signaling pathways 1. Genetically, PRR5-ARHGAP8 variants show significant association with binge eating behavior in bipolar disorder patients, with SNP rs726170 demonstrating genome-wide significance (OR = 1.91, P = 3.05E-08) in meta-analysis 1. At the expression level, PRR5-ARHGAP8 is upregulated in colon and stomach cancer specimens compared to non-tumorous tissue, suggesting acid-microenvironment responsiveness in cancer 2. Clinically, PRR5-ARHGAP8 emerges as a potential prognostic biomarker for colorectal cancer progression and survival 3. It was identified as a signature gene in both multivariate analyses and combined gene expression-clinical information analyses for colorectal cancer outcomes 3. These findings suggest PRR5-ARHGAP8 may represent a therapeutic target, though further investigation is warranted to clarify its mechanistic role across psychiatric and oncologic phenotypes.