Based on limited published evidence, PRSS58 encodes a serine-type endopeptidase involved in protein maturation within secretory granules. UniProt annotations indicate serine protease activity with extracellular localization (GO:0005615). PRSS58 is testis-enriched but not required for male fertility, as CRISPR/Cas9 knockout mice showed normal reproductive function 1. Suggestive epigenetic evidence links baseline PRSS58 DNA methylation to psychotherapy response in anxiety disorder treatment at 6-month follow-up 2. The specific proteolytic substrates and molecular mechanisms remain undefined.