2 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
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8PubMed Papers
12Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
GO:0005615secretory granuleprotein maturationserine-type endopeptidase activityovarian neoplasmnarcolepsy-cataplexy syndromeIGA glomerulonephritisgallbladder disease
Based on limited published evidence, PRSS58 encodes a serine-type endopeptidase involved in protein maturation within secretory granules. UniProt annotations indicate serine protease activity with extracellular localization (GO:0005615). PRSS58 is testis-enriched but not required for male fertility, as CRISPR/Cas9 knockout mice showed normal reproductive function 1. Suggestive epigenetic evidence links baseline PRSS58 DNA methylation to psychotherapy response in anxiety disorder treatment at 6-month follow-up 2. The specific proteolytic substrates and molecular mechanisms remain undefined.
1
PRSS58 knockout mice are male fertile with no observable reproductive defects, indicating the gene is not essential for male reproduction
PMID: 325619052
Baseline DNA methylation at PRSS58 showed suggestive association with psychotherapy response outcomes in anxiety disorders at 6-month follow-up
PMID: 40281224⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
ovarian neoplasmOpen Targets
narcolepsy-cataplexy syndromeOpen Targets
IGA glomerulonephritisOpen Targets
gallbladder diseaseOpen Targets
diabetic nephropathyOpen Targets
colonic neoplasmOpen Targets
metastatic neoplasmOpen Targets
Leigh syndromeOpen Targets
Crohn's diseaseOpen Targets
autoimmune pancreatitisOpen Targets
clear cell renal carcinomaOpen Targets
No pathogenic variants reported on ClinVar for this gene.