PSG7 (pregnancy-specific beta-1-glycoprotein 7) is a member of the carcinoembryonic antigen gene family located on chromosome 19.2 1. The gene encodes a glycoprotein that functions as a biomarker and potentially pathogenic factor in pregnancy complications. PSG7 expression is minimal in undifferentiated trophoblast cells but significantly increases during cytotrophoblast differentiation, serving as an early marker of trophoblast syncytialization 2. The protein contains an RGD sequence in its N-domain and has a unique unblocked N-terminal structure with a cysteine residue that may allow dimerization 3. Clinically, PSG7 demonstrates significant biomarker potential for preeclampsia, with elevated circulating levels observed weeks before disease onset and in established severe cases 4. The protein's expression and secretion are induced by inflammatory cytokines TNF-α and IL-6, suggesting placental inflammation drives its production 4. Recent Mendelian randomization studies indicate increased fetal PSG7 levels may causally contribute to increased birthweight 5. Additionally, PSG7 expression shows sex-specific associations with poor survival outcomes in female lung adenocarcinoma patients, potentially through KRAS signaling pathway modulation 6.