PXDN (peroxidasin) is a heme-containing peroxidase that plays critical roles in extracellular matrix (ECM) formation and cellular signaling. The enzyme primarily catalyzes the oxidation of bromide using hydrogen peroxide to generate hypobromous acid, which facilitates the formation of sulfilimine cross-links in collagen IV networks essential for basement membrane integrity 1. PXDN also mediates tyrosine bromination in various ECM proteins including laminins, collagen IV α2, and collagen VI α1, modifications that are present in both normal and fibrotic tissues 2. Beyond its structural roles, PXDN regulates cellular processes through multiple pathways. In cardiomyocytes, PXDN impairs autophagic flux by modulating FoxO1, contributing to insulin resistance-induced cell death 3. The protein promotes angiogenesis and epithelial-mesenchymal transition through PI3K/AKT signaling pathways 45. PXDN demonstrates significant clinical relevance as a pan-cancer biomarker, with elevated expression associated with poor prognosis across multiple tumor types 67. In cancer contexts, PXDN promotes tumor progression by enhancing cell proliferation and metastasis while simultaneously suppressing T-cell infiltration and activation 7. These findings establish PXDN as both a fundamental ECM organizer and a potential therapeutic target in various pathological conditions.