RAB14 is a small GTPase that regulates intracellular membrane trafficking by cycling between inactive GDP-bound and active GTP-bound states to recruit effector proteins 1. It functions in Golgi-to-endosome transport of FGFR-containing vesicles and mediates endosomal tethering through interaction with RUFY1 and RAB4B 2, while also potentially contributing to neurite formation via RAB11FIP1 interaction 3. Beyond canonical vesicular trafficking, RAB14 plays roles in cellular homeostasis and disease. It promotes Parkin-dependent mitophagy through TGN-derived vesicles and TBK1/PI3K signaling, reducing mitochondrial protein levels and maintaining cellular metabolism 4. RAB14 is regulated by miR-144 and miR-451 during erythropoiesis, where it acts as a physiological inhibitor 5. In nasopharyngeal carcinoma, the CPT1A-RAB14 interaction facilitates fatty acid trafficking from lipid droplets to mitochondria, promoting radiation resistance 6. During Mycobacterium tuberculosis infection, the bacterial effector PknG targets RAB14 to block autophagosome maturation and enhance pathogen survival 7. RAB14 also regulates cytokinesis efficiency through MACF2 interaction and endosome recruitment to the cleavage furrow 8. Clinically, RAB14 levels in circulating CD14+ monocytes serve as a biomarker for liver fibrosis, achieving 99.3% accuracy in detecting non-alcoholic steatohepatitis 9.