RAB22A is a small GTPase that regulates intracellular membrane trafficking and endosomal recycling pathways with significant implications in cancer biology. As a member of the RAS oncogene family, RAB22A functions as a molecular switch controlling vesicle formation, transport, and fusion between cellular compartments 1. The protein plays crucial roles in endocytic recycling by sorting cargo from early endosomes to recycling endosomes, preventing lysosomal degradation through RAB7A inactivation via recruitment of TBC1D2B, while simultaneously activating RAB11A through SH3BP5L engagement 2. RAB22A mediates the trafficking of key proteins including transferrin and EGFR, with EGFR phosphorylating RAB22A at Tyr136 to promote microvesicle formation 2. In immune contexts, RAB22A regulates MHC-I trafficking and antigen cross-presentation by dendritic cells 1. The protein also orchestrates non-canonical autophagy, forming 'Rafesomes' that enable intercellular transfer of activated STING to promote antitumor immunity 3. Disease relevance includes oncogenic fusion proteins (Rab22a-NeoFs) in osteosarcoma that drive lung metastasis through RhoA activation 45. High RAB22A expression correlates with improved survival in nasopharyngeal cancer patients receiving chemoradiotherapy, highlighting its clinical significance as both a therapeutic target and prognostic marker 3.