RAB30 is a small GTPase that primarily localizes to the Golgi apparatus and trans-Golgi network, where it serves multiple critical functions in membrane trafficking and cellular homeostasis 12. The protein is essential for maintaining the structural integrity of the Golgi apparatus through continuous recruitment to Golgi membranes, though it does not impair conventional anterograde or retrograde transport 1. RAB30 regulates retrograde trafficking of cargo like TGN38 from endosomes to the Golgi and maintains endosome-TGN organization by interacting with Arf1 and Arf4 2. During bacterial infections, particularly Group A Streptococcus, RAB30 promotes autophagosome biogenesis by recruiting PI4KB to generate phosphatidylinositol-4-phosphate, facilitating the formation of pathogen-containing autophagosome-like vacuoles independently of its Golgi maintenance role 34. In hepatic metabolism, RAB30 expression is induced during fasting in a PPARα-dependent manner and facilitates lipid homeostasis by regulating hepatic protein and lipid trafficking, particularly affecting circulating triglyceride levels and ApoA4 secretion 5. RAB30 also shows elevated expression during liver regeneration, suggesting roles in hepatocyte functional adaptation 6.