RABL6 is a small GTPase that functions as a key regulator of cell growth, proliferation, and survival. The protein promotes cellular proliferation and may reduce growth inhibitory activity of CDKN2A 1. RABL6 operates through multiple mechanisms including regulation of the RB1 tumor suppressor pathway, where it inhibits RB1 to prevent cellular senescence and maintain proliferative capacity 2. The gene is required for proper cell cycle progression and its silencing leads to premature stress-induced senescence 2. In cancer contexts, RABL6 demonstrates significant oncogenic properties across multiple tumor types. It is overexpressed in esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, and urothelial bladder carcinoma 3456. High RABL6 expression correlates with poor prognosis and promotes tumor cell proliferation, invasion, and metastasis while inhibiting apoptosis 34. The protein also regulates epithelial-mesenchymal transition in cancer cells 3. Clinically, RABL6 serves as both a prognostic biomarker and potential therapeutic target, with patients showing high RABL6 expression demonstrating significantly worse overall survival outcomes 56.