RALBP1 (RalA Binding Protein 1) is a multifunctional membrane protein that serves as an ATP-dependent transporter of glutathione conjugates and xenobiotics, including chemotherapy drugs like doxorubicin 1. The protein functions as a critical regulator of cellular transport processes, contributing to multidrug resistance by facilitating the efflux of toxic compounds 2. RALBP1 operates through multiple mechanisms, including participation in a Reps1-Ralbp1-RalA module that regulates exocytosis by maintaining RalA in an active GTP-bound state, thereby controlling surface protein levels 3. The protein also plays essential roles in synaptic function, where regulated interactions between RalBP1, RalA, and PSD-95 control AMPA receptor endocytosis during long-term depression 4. RALBP1 expression is induced by inflammatory signals like TNF-α, particularly in blood-brain barrier endothelial cells, suggesting roles in neuroinflammation 5. Clinically, RALBP1 is overexpressed in various cancers including lung, ovarian carcinomas, and melanomas 1. Its inhibition by proteins like Hsf-1 and POB1 increases drug sensitivity and apoptosis in cancer cells 6, while its degradation can suppress PI3K/Akt/mTOR signaling in gastric cancer 7. These findings position RALBP1 as a potential therapeutic target for cancer treatment and drug resistance.