RASA4B — RAS p21 protein activator 4B

5 sources retrieved · Most recent: April 2026 · Index updated 5 months ago

8PubMed Papers

#17,761 · top 91% of 19K genes

7Diseases

top 87%

0Drugs

0Pathogenic Variants

Experimental GO EvidenceSwiss-Prot Reviewed

GTPase activator activityregulation of intracellular signal transductionintracellular signal transductionnegative regulation of Ras protein signal transductionneurodegenerative diseasecircadian rhythmtype 2 diabetes mellitusasthma

AI Summary

AI summary not yet available. Showing NCBI Gene summary.

RAS p21 protein activator 4B

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations7

neurodegenerative diseaseOpen Targets

0.34Weak

circadian rhythmOpen Targets

0.11Weak

type 2 diabetes mellitusOpen Targets

0.03Suggestive

asthmaOpen Targets

0.01Suggestive

breast cancerOpen Targets

0.00Suggestive

breast carcinomaOpen Targets

0.00Suggestive

uterine corpus endometrial carcinomaOpen Targets

0.00Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Tissue Expression6 tissues

Ovary

100%

Lung

52%

Brain

28%

Liver

14%

Bone Marrow

Heart

Gene Interaction Network6 neighbors

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StructureAlphaFold

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AlphaFoldAI-predicted · UniProt C9J798

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ConstraintgnomAD v4.1

LOEUFⓘ

1.65LoF Tolerant

pLIⓘ

0.29Tolerant

Observed/Expected LoF0.42 [0.14–1.65]

Rankings2 dim

Where RASA4B stands among ~20K protein-coding genes

#17,692of 20,598
Most Researched8
#15,921of 17,882
Most Constrained (LOEUF)1.65