RBM23 (RNA binding motif protein 23) is a multifunctional RNA-binding protein that functions as both a transcription coactivator and pre-mRNA splicing factor 1. RBM23 regulates steroid hormone receptor-mediated transcription independently of its splicing activities 1. Structurally, RBM23 shares a conserved degron motif in its RRM2 domain with RBM39, making it susceptible to recruitment by the CRL4-DCAF15 E3 ubiquitin ligase when targeted by aryl-sulfonamide drugs like indisulam 23. However, unlike RBM39, RBM23 degradation does not substantially alter gene expression patterns or cause widespread splicing defects 3. In disease contexts, circular RNA derived from RBM23 (circ_RBM23) promotes hepatocellular carcinoma progression by activating NF-κB signaling and enhancing angiogenesis 4, while also driving sorafenib chemoresistance through the miR-338-3p/RAB1B axis 5. Conversely, circ_RBM23 promotes hepatocyte proliferation and liver regeneration by competing for miR-139-5p binding 6, and regulates mesenchymal stem cell differentiation by suppressing miR-338-3p to promote osteogenesis over adipogenesis 7. These context-dependent roles highlight RBM23's importance in both normal cellular processes and pathological conditions.