RBM24 (RNA binding motif protein 24) is a highly conserved RNA-binding protein that serves as a multifaceted post-transcriptional regulator of gene expression with critical roles in tissue development and homeostasis 1. The protein exhibits tissue-specific expression patterns, particularly in skeletal and cardiac muscles, with dynamic subcellular localization during development 1. RBM24 functions through multiple post-transcriptional mechanisms including mRNA stabilization, splicing regulation, and translational control 1. In cardiovascular biology, RBM24 S181 phosphorylation through eIF4E2-GSK3β signaling promotes APOE translation, linking psychological stress to cardiovascular disease 2. The protein also regulates vascular smooth muscle cell phenotypic switching by stabilizing JAK2 mRNA and activating the JAK2-STAT3-KLF4 signaling pathway, promoting vascular remodeling 3. In cancer contexts, RBM24 displays dual functionality, acting as both tumor suppressor and oncogene depending on tissue context, with dysregulation frequently observed across human cancers 4. The protein regulates cellular differentiation, proliferation, and migration through context-dependent mechanisms 45. RBM24's essential role in muscle development and regeneration, combined with its involvement in disease pathogenesis, makes it an important therapeutic target and potential biomarker 6.