RBM26 (RNA binding motif protein 26) is a nuclear RNA-binding protein that plays critical roles in RNA metabolism and quality control. The protein functions as an essential component of the Poly(A) Tail eXosome Targeting (PAXT) complex, which facilitates the degradation of nuclear polyadenylated RNA by recruiting the RNA exosome 1. RBM26, along with RBM27, can be recruited by PABPN1 to promote splicing of terminal introns, particularly those with weak 3' splice sites 2. The protein also participates in nuclear RNA sorting mechanisms, where it acts as a transient PAXT component that helps trigger exosomal degradation of shorter RNAs while allowing longer RNAs to proceed to nuclear export 3. Disease relevance studies have identified RBM26 as a significant risk gene in genome-wide association studies for tic disorders, suggesting its importance in neurological function 4. Additionally, RBM26 variants have been associated with coal workers' pneumoconiosis risk in Chinese populations, with the gene showing lung tissue-specific expression patterns 5. The protein's RNA-binding and regulatory functions position it as a key player in nuclear RNA surveillance and processing pathways.