RBM28 is a nucleolar RNA-binding protein that functions as a component of spliceosomal ribonucleoprotein complexes 1. It specifically associates with U1, U2, U4, U5, and U6 snRNAs and coordinates their transition through the nucleolus 1. Under cellular stress, RBM28 translocates from the nucleolus to the nucleoplasm via phosphorylation at Ser122 by Chk1/2 kinases, functioning as a nucleolar stress sensor 2. In the nucleoplasm, RBM28 interacts with the DNA-binding domain of p53 tumor suppressor to inhibit its transcriptional activity 23. Additionally, RBM28 enhances STAT3 translation in hepatocellular carcinoma by recruiting EIF4E to STAT3 mRNA, promoting angiogenesis and tumor progression 4. RBM28 is upregulated in various cancers and associated with poor prognosis 2. Loss-of-function mutations in RBM28 cause ANE (alopecia, neurologic defects, and endocrinopathy) syndrome, a ribosomopathy characterized by combined anterior pituitary hormone deficiency and impaired 60S ribosomal subunit assembly 56. RBM28 also participates in stress granule formation under cellular stress conditions 7.