RBM8A encodes an RNA-binding motif protein that serves as a core component of the exon junction complex (EJC), essential for multiple aspects of RNA metabolism 1. The protein forms a heterodimer with MAGOH and is required for pre-mRNA splicing, mRNA export, translation, and nonsense-mediated mRNA decay 1. The RBM8A-MAGOH complex stabilizes the EJC by inhibiting EIF4A3 ATPase activity, trapping the complex onto spliced mRNAs throughout their lifecycle 1. Beyond its canonical EJC functions, RBM8A localizes to centrosomes and is required for proper M-phase progression 2. The protein is clinically significant as compound inheritance of a rare null allele with regulatory SNPs in RBM8A causes thrombocytopenia-absent radius (TAR) syndrome, demonstrating that Y14 insufficiency leads to this congenital malformation disorder 3. RBM8A is overexpressed in multiple cancers including hepatocellular carcinoma and gastric cancer, where it promotes tumor progression by stabilizing oncogenic mRNAs such as EGFR, contributing to chemotherapy resistance 456. In breast cancer, RBM8A is transcriptionally activated by TEAD4 and promotes malignancy by regulating IGF1R and IRS-2 expression through the PI3K/AKT pathway 7.