RELCH (RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing) is a membrane tethering protein that regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network 1. The protein functions by binding to active RAB11-GTP on recycling endosomes and OSBP on Golgi-like membranes, thereby tethering these compartments together 1. RELCH promotes nonvesicular cholesterol transfer between these membrane systems through OSBP-mediated mechanisms 1. In vitro reconstitution studies demonstrated that RELCH depletion impairs cholesterol accumulation at the trans-Golgi network, with cholesterol accumulating instead in late endosomes/lysosomes 1. Beyond its canonical cholesterol transport function, RELCH has been implicated in congenital deafness based on conserved vertebrate brain protein interaction networks 2. The gene has also been identified in fusion events with RET in papillary thyroid carcinoma, where KIAA1468-RET (RELCH-RET) fusions produce aberrant proteins combining RELCH's LisH and coiled-coil domains with RET's tyrosine kinase domain 3. These findings establish RELCH as essential for lipid homeostasis and suggest additional roles in neural development and potential oncogenic contexts.