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GeneE
10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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RFK
riboflavin kinase
Chromosome 9 · 9q21.13
NCBI Gene: 55312Ensembl: ENSG00000135002.12HGNC: HGNC:30324UniProt: B2RDZ2
25PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
ApoptosisKinase
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
mitochondrionpositive regulation of NAD(P)H oxidase activityprotein bindingriboflavin kinase activityneurodegenerative diseasealcohol drinkingAbnormality of the skeletal systemtrauma complication
✦AI Summary

Unable to provide a gene function summary for RFK (riboflavin kinase) based on the provided PubMed abstracts. The six abstracts supplied focus on obesity pharmacotherapy (semaglutide and tirzepatide trials), post-traumatic epilepsy, and blood-brain barrier dysfunction in neurodegeneration. None contain information about RFK gene function, mechanism, disease relevance, or clinical significance. To write an accurate, evidence-based summary grounded in PubMed literature, abstracts specifically addressing RFK biology, its role in flavin metabolism, TNF-induced ROS production, NADPH oxidase coupling, or RFK-associated diseases would be required.

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
neurodegenerative diseaseOpen Targets
0.46Moderate
alcohol drinkingOpen Targets
0.12Weak
Abnormality of the skeletal systemOpen Targets
0.11Weak
trauma complicationOpen Targets
0.09Suggestive
acute myeloid leukemiaOpen Targets
0.07Suggestive
CachexiaOpen Targets
0.06Suggestive
heart conduction diseaseOpen Targets
0.05Suggestive
glaucomaOpen Targets
0.05Suggestive
bile duct disorderOpen Targets
0.05Suggestive
lymphangiomaOpen Targets
0.05Suggestive
hemangiomaOpen Targets
0.04Suggestive
neoplasmOpen Targets
0.04Suggestive
Testicular regression syndromeOpen Targets
0.04Suggestive
response to antihypertensive drugOpen Targets
0.04Suggestive
cryptorchidismOpen Targets
0.04Suggestive
renal hypodysplasia/aplasia 3Open Targets
0.04Suggestive
pericarditisOpen Targets
0.03Suggestive
nephronophthisisOpen Targets
0.03Suggestive
46,XY complete gonadal dysgenesisOpen Targets
0.03Suggestive
congenital bilateral absence of vas deferensOpen Targets
0.03Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
NOXO1Protein interaction100%TNFRSF1AProtein interaction98%TRADDProtein interaction98%NOX1Protein interaction98%ENPP1Protein interaction93%ACP5Protein interaction92%
Tissue Expression6 tissues
Bone Marrow
100%
Brain
81%
Heart
49%
Liver
39%
Ovary
18%
Lung
14%
Gene Interaction Network
Click a node to explore
RFKNOXO1TNFRSF1ATRADDNOX1ENPP1ACP5
PROTEIN STRUCTURE
Preparing viewer…
PDB1NB0 · 1.70 Å · X-ray
View on RCSB ↗
Constraintⓘ
LOEUFⓘ
0.56Moderately Constrained
pLIⓘ
0.91Intolerant
Observed/Expected LoF0.12 [0.04–0.56]
RankingsWhere RFK stands among ~20K protein-coding genes
  • #13,051of 20,598
    Most Researched25
  • #3,613of 17,882
    Most Constrained (LOEUF)0.56 · top quartile
Genes detectedRFK
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
Once-Weekly Semaglutide in Adults with Overweight or Obesity.
PMID: 33567185
N Engl J Med · 2021
1.00
2
Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension.
PMID: 35441470
Diabetes Obes Metab · 2022
0.90
3
Long-term weight loss effects of semaglutide in obesity without diabetes in the SELECT trial.
PMID: 38740993
Nat Med · 2024
0.80
4
Body composition changes during weight reduction with tirzepatide in the SURMOUNT-1 study of adults with obesity or overweight.
PMID: 39996356
Diabetes Obes Metab · 2025
0.70
5
Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes.
PMID: 37952131
N Engl J Med · 2023
0.60