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GeneE
0 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
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RGMB
repulsive guidance molecule BMP co-receptor b
Chromosome 5 Β· 5q15
NCBI Gene: 285704Ensembl: ENSG00000174136.13HGNC: HGNC:26896UniProt: J3KNF6
23PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
protein bindingcoreceptor activityidentical protein bindingcell adhesionAbnormality of the skeletal systemcarpal tunnel syndromebenign prostatic hyperplasiaAlzheimer disease
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

repulsive guidance molecule BMP co-receptor b

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
Abnormality of the skeletal systemOpen Targets
0.43Moderate
carpal tunnel syndromeOpen Targets
0.35Weak
benign prostatic hyperplasiaOpen Targets
0.34Weak
Alzheimer diseaseOpen Targets
0.32Weak
multiple sclerosisOpen Targets
0.31Weak
lysosomal storage diseaseOpen Targets
0.31Weak
neurodegenerative diseaseOpen Targets
0.31Weak
Parkinson diseaseOpen Targets
0.31Weak
osteoarthritisOpen Targets
0.29Weak
frozen shoulderOpen Targets
0.27Weak
glomerulonephritisOpen Targets
0.27Weak
Peyronie diseaseOpen Targets
0.27Weak
alcohol drinkingOpen Targets
0.21Weak
ConstipationOpen Targets
0.20Weak
cataractOpen Targets
0.20Weak
hemorrhoidOpen Targets
0.19Weak
trauma complicationOpen Targets
0.19Weak
disorder of earOpen Targets
0.17Weak
enteritisOpen Targets
0.17Weak
brain cancerOpen Targets
0.17Weak
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
PDCD1LG2Protein interaction97%NEO1Protein interaction93%NTN1Protein interaction93%GDF5Protein interaction92%DRGXProtein interaction88%ACVR1Protein interaction83%
Tissue Expression6 tissues
Brain
100%
Ovary
41%
Heart
30%
Lung
19%
Liver
18%
Bone Marrow
3%
Gene Interaction Network
Click a node to explore
RGMBPDCD1LG2NEO1NTN1GDF5DRGXACVR1
PROTEIN STRUCTURE
Preparing viewer…
PDB6Z3J Β· 1.65 Γ… Β· X-ray
View on RCSB β†—
Constraintβ“˜
LOEUFβ“˜
0.93LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF0.61 [0.41–0.93]
RankingsWhere RGMB stands among ~20K protein-coding genes
  • #13,504of 20,598
    Most Researched23
  • #8,525of 17,882
    Most Constrained (LOEUF)0.93
Genes detectedRGMB
Sources retrieved0 papers
Response timeβ€”