RGS7BP (regulator of G protein signaling 7 binding protein) functions as a regulatory subunit controlling G protein-coupled receptor (GPCR) signaling by modulating the subcellular localization and stability of R7-Gβ5 complexes 1. When palmitoylated, RGS7BP targets R7-Gβ5 complexes to the plasma membrane to inhibit G protein alpha subunits; when unpalmitoylated, it permits nuclear/cytoplasmic shuttling of these complexes 2. RGS7BP also protects R7 proteins from proteolytic degradation 3. The protein is highly expressed in blood vessels and brain tissue 4, with distinct expression in brown adipocyte progenitors 5. Clinically, RGS7BP variants associate with multiple psychiatric and neurological conditions. Uncommon coding variants in RGS7BP enriched in suicide attempt cases, with aberrant brain expression in individuals deceased from suicide 6. A chromosome 5.3 deletion involving RGS7BP segregates with familial epilepsy and migraine with aura 7. Additionally, RGS7BP gene polymorphisms associate with aspirin-exacerbated respiratory disease in asthmatic patients through modulation of muscarinic receptor responsiveness 2. Genome-wide association analysis identified RGS7BP intronic variants significantly associated with tuberculosis severity 4.