Based on limited published evidence, RHBDL1 is a serine-type endopeptidase localized to the plasma membrane involved in regulated intramembrane proteolysis and release of functional polypeptides from membrane anchors. UniProt annotations indicate protein binding and signal transduction functions. Unlike the related protease RHBDL2, which catalyzes ectodomain shedding of CLEC14A to regulate angiogenesis 1, RHBDL1 does not cleave this substrate. RHBDL1 has been identified as part of a 4-gene radiotherapy-response signature in WHO grade 4 gliomas 2, though its specific mechanistic role requires further investigation.