RICTOR is an essential scaffold component of mTORC2 (mechanistic target of rapamycin complex 2) that transduces growth factor signals to regulate cell proliferation, cytoskeletal organization, and metabolism 12. Within mTORC2, RICTOR acts as a molecular adapter 3 and mediates the complex's resistance to rapamycin inhibition 4. A primary function is facilitating AKT/PKB activation by phosphorylating Ser473 in the hydrophobic motif, which cooperates with PDK1-mediated Thr308 phosphorylation for full kinase activation 2. mTORC2 also phosphorylates PKC and SGK1 family members and regulates actin cytoskeleton dynamics through Rho GTPase signaling 5. Unlike mTORC1, mTORC2 is nutrient-insensitive, maintaining signaling during metabolic stress 3. Clinically, RICTOR dysregulation contributes to multiple malignancies. In melanoma, low RICTOR levels correlate with worse prognosis and BRAF inhibitor resistance through enhanced mitochondrial respiration 6. RICTOR activation promotes stemness in hepatocellular carcinoma under glutamine starvation via HDAC3-mediated stabilization of glutamine synthetase 7. RICTOR is upregulated in neuroendocrine prostate cancer and glioblastoma, supporting tumor aggressiveness and chemoresistance 89. In kidney transplantation, RICTOR/mTORC2 activation drives endothelial-to-mesenchymal transition and interstitial fibrosis through BNIP3-regulated mitophagy 10. These findings identify RICTOR as a potential therapeutic target across multiple cancer types and fibrotic diseases.