HomeAboutRankingsData Sources
© 2026 GeneE
🧬
GeneE
10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
ⓘGeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
RRH
retinal pigment epithelium-derived rhodopsin homolog
Chromosome 4 · 4q25
NCBI Gene: 10692Ensembl: ENSG00000180245.7HGNC: HGNC:10450UniProt: O14718
11PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Receptor
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingplasma membranecellular response to light stimulusG protein-coupled photoreceptor activityStargardt diseaseDNA methylationprostate carcinomacolor vision disorder
✦AI Summary

I cannot provide a gene function summary for RRH based on the provided PubMed abstracts. The four abstracts supplied address Indigenous healthcare practices, trauma-informed care, melioidosis diagnosis, and Aboriginal birthing practices—none of which contain relevant information about RRH (retinal pigment epithelium-derived rhodopsin homolog) function, mechanism, or clinical significance. To accurately summarize RRH biology, abstracts specifically investigating this gene's molecular function, G protein-coupled receptor signaling, phototransduction pathways, retinal pigment epithelium physiology, or associations with retinal disease would be required. The NCBI and UniProt annotations suggest RRH functions as a light-detecting GPCR involved in retinoid metabolism within the RPE, but this summary cannot be grounded in the provided literature.

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
Stargardt diseaseOpen Targets
0.33Weak
DNA methylationOpen Targets
0.31Weak
prostate carcinomaOpen Targets
0.29Weak
color vision disorderOpen Targets
0.29Weak
congenital stationary night blindnessOpen Targets
0.15Weak
retinitis pigmentosaOpen Targets
0.02Suggestive
retinal degenerationOpen Targets
0.01Suggestive
congenital stationary night blindness, recessiveOpen Targets
0.01Suggestive
HepatitisOpen Targets
0.01Suggestive
age-related macular degenerationOpen Targets
0.01Suggestive
neoplasmOpen Targets
0.01Suggestive
retinitis pigmentosa 1Open Targets
0.01Suggestive
uterine leiomyosarcomaOpen Targets
0.00Suggestive
autosomal recessive retinitis pigmentosaOpen Targets
0.00Suggestive
Retinal dystrophyOpen Targets
0.00Suggestive
retinitis punctata albescensOpen Targets
0.00Suggestive
cervical cancerOpen Targets
0.00Suggestive
digestive system infectious disorderOpen Targets
0.00Suggestive
atherosclerosisOpen Targets
0.00Suggestive
hepatitis C virus infectionOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
LRIT3Protein interaction83%RGRShared pathway80%OPN1MWShared pathway57%OPN1LWShared pathway57%OPN1MW2Shared pathway57%OPN1MW3Shared pathway57%
Tissue Expression6 tissues
Bone Marrow
100%
Brain
81%
Liver
49%
Ovary
41%
Lung
27%
Heart
0%
Gene Interaction Network
Click a node to explore
RRHLRIT3RGROPN1MWOPN1LWOPN1MW2OPN1MW3
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted · UniProt O14718
View on AlphaFold ↗
Constraintⓘ
LOEUFⓘ
1.36LoF Tolerant
pLIⓘ
0.00Tolerant
Observed/Expected LoF1.01 [0.75–1.36]
RankingsWhere RRH stands among ~20K protein-coding genes
  • #16,886of 20,598
    Most Researched11
  • #14,245of 17,882
    Most Constrained (LOEUF)1.36
Genes detectedRRH
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
Ticking the box of 'cultural safety' is not enough: why trauma-informed practice is critical to Indigenous healing.
PMID: 34237994
Rural Remote Health · 2021
1.00
2
Researching 'others'.
PMID: 34210146
Rural Remote Health · 2021
0.90
3
Melioidosis: a review.
PMID: 25359677
Rural Remote Health · 2014
0.80
4
Our hope.
PMID: 17650059
Rural Remote Health · 2007
0.70
5
Pandemic.
PMID: 19534567
Rural Remote Health · 2009
0.60