SCAMP4 is a secretory carrier membrane protein involved in exocytic trafficking and membrane protein transport through the trans-Golgi network and recycling endosomes 1. Functionally, SCAMP4 accumulates on senescent cell surfaces and critically enhances secretion of senescence-associated secretory phenotype (SASP) factors including IL-6, IL-8, GDF-15, CXCL1, and IL-7, with SCAMP4 silencing reducing factor secretion while overexpression increases it 1. Clinically, SCAMP4 is a dysregulated membrane protein with significant disease relevance. In colorectal cancer, SCAMP4 is overexpressed in tumor tissues and represents a direct target of the tumor-suppressive miR-1908-5p; high SCAMP4 expression correlates with advanced TNM stage, nodal metastasis, elevated CA19-9 levels, and poor survival 2. Similarly, in glioma (low-grade and glioblastoma), elevated SCAMP4 is an independent prognostic factor correlated with tumor grade, stage, and immune infiltration by monocytes, NK cells, and macrophages 3. In pancreatic adenocarcinoma, SCAMP4 is upregulated compared to normal tissue 4. Additionally, SCAMP4 expression in brain regions associated with female reproductive behavior is repressed by progesterone following estrogen priming, suggesting roles in neuroendocrine function 5. Collectively, these findings establish SCAMP4 as a promising biomarker for cancer prognosis and progression.