SCN7A encodes an atypical sodium channel (Nax) that functions as a sodium leak channel and osmosensor, distinct from conventional voltage-gated sodium channels 1. Unlike voltage-gated channels, SCN7A allows sodium flow along concentration gradients and serves as a sensor for extracellular sodium concentrations 2. The channel plays a critical role in sodium homeostasis and blood pressure regulation, with polymorphisms significantly associated with essential hypertension in Chinese populations 34. In the central nervous system, SCN7A expression is upregulated in epileptic tissue, where it is found in both neurons and reactive astrocytes, suggesting involvement in epileptogenesis 1. The protein may function as an early sensor detecting tissue homeostasis loss through pathological sodium accumulation, subsequently promoting pro-inflammatory and pro-fibrotic responses 2. Clinically, SCN7A has emerged as a prognostic biomarker in multiple cancers, including esophageal squamous cell carcinoma and gastric cancer, where its expression correlates with survival outcomes 56. Additionally, SCN7A expression has been identified in various inflammatory conditions, including benign prostate hyperplasia and eosinophilic granulomatosis with polyangiitis, indicating broader roles in pathological processes 78.