SCRT1 (scratch family transcriptional repressor 1) is a zinc finger transcriptional repressor that binds to E-box motifs and regulates gene expression in multiple biological contexts 1. In pancreatic β-cells, SCRT1 acts as a key regulator of insulin secretion and β-cell proliferation 23. SCRT1 directly binds to E-boxes in the insulin gene promoter and its silencing impairs glucose-stimulated insulin secretion and reduces insulin gene expression 3. The protein exhibits glucose-dependent subcellular localization, translocating between nucleus and cytosol, and is regulated by GSK3β-dependent phosphorylation 3. SCRT1 expression is controlled by REST and increases during β-cell maturation 2. In disease contexts, SCRT1 expression is reduced in β-cells from type 2 diabetes patients, correlating with impaired insulin secretion capacity 3. Unlike other SNAIL family members, SCRT1 is not expressed in human tumors, suggesting it lacks oncogenic properties 4. However, SCRT1 can be aberrantly upregulated in anti-Mi2-positive dermatomyositis muscle tissue due to CHD4/NuRD complex inhibition 5. Additionally, SCRT1 functions as a transcriptional repressor during neuronal reprogramming, helping to suppress microglial gene expression during microglia-to-neuron conversion 6.