SFMBT1 (Scm-like with four MBT domains 1) is a chr3 reader protein that functions as a transcriptional repressor through recognition of repressive histone marks 1. The protein operates as a core component of multiple corepressor complexes, including CtBP/LSD1/HDAC complexes and polycomb repressive complexes, which collectively mediate epigenetic silencing and chr3 compaction 1. SFMBT1 forms a stable complex with LSD1 and CoREST to regulate histone gene expression and cell cycle-dependent transcriptional repression 2. During myogenesis, SFMBT1 maintains myogenic progenitor cells in an undifferentiated state by interacting with MYOD1 and recruiting corepressors to silence MYOD1 target genes 1. Beyond development, SFMBT1 plays pathological roles in multiple diseases. In clear cell renal cell carcinoma, SFMBT1 acts as an oncogenic driver regulated by the pVHL-SFMBT1-SPHK1 axis, with SFMBT1 depletion inhibiting tumor growth 3. In cervical cancer, elevated SFMBT1 expression promotes epithelial-mesenchymal transition and invasion, and is normally repressed by miR-218 4. Additionally, SFMBT1 variants are associated with hypertension susceptibility in Han Chinese populations 5 and schizophrenia risk through altered neurodevelopment and dendritic spine density 6.