SHANK2 encodes a postsynaptic scaffolding protein that functions as an adapter in the postsynaptic density (PSD) of excitatory glutamatergic synapses 1. The protein interconnects receptors of the postsynaptic membrane, including NMDA-type and metabotropic glutamate receptors, with the actin-based cytoskeleton, playing a crucial role in structural and functional organization of dendritic spines and synaptic junctions 1. SHANK2 is essential for synaptic plasticity, with expression levels affecting synaptic-related proteins and transmission efficiency 2. The gene shows isoform-specific expression patterns, with SHANK2B being particularly abundant in ALDH1A1 negative dopamine neurons during early neuronal development 3. Pathogenic variants and deletions in SHANK2 are associated with autism spectrum disorder (ASD), intellectual disability, developmental delay, and ADHD 45. Clinical manifestations include mild to moderate developmental impairment, speech delays, poor language skills, sensory abnormalities, and high rates of autism 45. Mouse models with SHANK2 mutations exhibit autistic-like behaviors and altered dopamine neuron function 36, supporting its critical role in neurodevelopment and synaptic function.