SHC3 (Src homology and collagen homology 3) is a neuronal signaling adapter protein that couples activated receptor tyrosine kinases to downstream intracellular pathways 1. In the central nervous system, SHC3 functions primarily in growth factor receptor signaling, particularly in neurons 1. Mechanistically, SHC3 operates as a multiprotein scaffold that interacts with various signaling molecules. It binds activated growth factor receptors (including ErbB2) and transduces signals through interactions with FAK, MVP, AP complexes, and other effectors 2345. SHC3 undergoes tyrosine phosphorylation upon activation and modulates downstream kinase cascades including MEK/ERK and AKT pathways 634. Clinically, SHC3 dysregulation associates with multiple malignancies and psychiatric disease. Genetic variants in SHC3 show significant association with schizophrenia susceptibility in the Han Chinese population 1. In cancer, SHC3 is frequently amplified or overexpressed in glioblastomas, ependymomas, hepatocellular carcinomas, and breast cancers 2647. Elevated SHC3 promotes drug resistance through MDR1/P-glycoprotein upregulation and enhances tumor stemness, metastasis, and glucose adaptation 3745. These findings identify SHC3 as a potential therapeutic target in both cancer and neuropsychiatric disorders.