SLC17A3 encodes a voltage-driven, multispecific organic anion transporter localized on the apical membrane of renal proximal tubular epithelial cells 1. The primary function is mediating renal secretion of urate, the end product of purine metabolism, from cells into the urinary lumen 1. The transporter also handles diverse substrates including drugs (bumetanide, furosemide), steroid conjugates (estrone sulfate, estradiol-17-beta-glucuronide), toxins (ochratoxin A), and metabolites like N-lactoyl-phenylalanine (Lac-Phe) and 3-indoxyl sulfate 123. SLC17A3 operates through voltage-driven efflux mechanisms, with demonstrated transport kinetics for substrates like 3-indoxyl sulfate (Km = 4.52 mM) 3. Loss-of-function mutations in SLC17A3 cause urate underexcretion, contributing to hyperuricemia and gout susceptibility 4. Clinical significance includes associations with hyperuricemia, gout, and potentially ischemic stroke risk in certain populations 5. Genetic variants account for significant portions of serum urate variance and may influence type 1 diabetes susceptibility in consanguineous populations 6. The transporter represents a critical component of renal organic anion elimination pathways.