SLC25A16 is a mitochondrial inner membrane transporter that regulates coenzyme A (CoA) homeostasis between the cytosol and mitochondria 1. The protein mediates import of free CoA from the cytosol into the mitochondrial matrix 2, supporting an enriched mitochondrial CoA pool essential for energy metabolism pathways including the TCA cycle and fatty acid oxidation 2. Alternatively, SLC25A16 may function in exporting 3'-dephospho-CoA from mitochondria to the cytosol 3. This CoA compartmentalization enables spatial regulation of anabolic and catabolic processes 2. Diseases involving SLC25A16 dysfunction have emerged from multiple genetic studies. A genome-wide association study identified SLC25A16 variants associated with stimulant dependence in African-ancestry populations (rs2394476, p = 3.42 × 10⁻¹⁰) 4. SLC25A16 was identified as a core druggable target in diabetic nephropathy, a mitochondrial dysfunction-related kidney disease 5. Additionally, SLC25A16 variants were identified as candidate genes in cerebral visual impairment cases 6, and altered SLC25A16 expression was associated with birth weight changes following prenatal metabolic disruption 7. These findings suggest SLC25A16's role in metabolic diseases warrants further clinical investigation.