SLC25A28, also known as mitoferrin-2 (MFRN2), is a mitochondrial iron transporter that mediates iron uptake into mitochondria and plays crucial roles in cellular iron homeostasis 12. The protein is essential for mitochondrial respiration and iron-sulfur cluster protein function, as its deficiency profoundly impairs these processes and leads to DNA damage and cell death 1. SLC25A28 exhibits synthetic lethal interactions with its paralog SLC25A37 (MFRN1), making it an attractive therapeutic target in cancers where SLC25A37 is homozygously deleted 13. The gene demonstrates significant disease relevance in cancer biology, where it promotes ferroptosis - an iron-dependent form of cell death - through mechanisms involving iron accumulation and mitochondrial dysfunction 245. In hepatic stellate cells, SLC25A28 forms complexes with p53 to enhance iron accumulation and electron transport chain hyperfunction, contributing to ferroptotic cell death 2. Clinically, SLC25A28 represents a promising therapeutic target, as knockout mice display minimal toxicity except for cataracts in some animals, suggesting that inhibition strategies may have acceptable safety profiles 3. The protein's role in iron homeostasis and ferroptosis makes it relevant for treating various cancers, liver fibrosis, and other iron-related disorders.