SLC27A1 (FATP1) is a long-chain fatty acid transporter that mediates LCFA import into cells at the plasma membrane 1. Beyond transport, SLC27A1 functions as an acyl-CoA ligase, catalyzing ATP-dependent formation of fatty acyl-CoA from LCFA and VLCFA substrates, which traps fatty acids intracellularly and drives continued uptake 1. The protein is highly expressed in metabolically active tissues including muscle, adipose tissue, and heart, with minimal expression in liver 1. SLC27A1 plays a pivotal role in tissues undergoing high β-oxidation or triglyceride synthesis, regulating exogenous LCFA availability 1. At the blood-brain barrier, SLC27A1 supplies docosahexaenoic acid to the brain 2, and cold-induced lipokine 12,13-diHOME enhances BAT thermogenesis by promoting SLC27A1 translocation to the cell membrane, increasing fatty acid uptake 3. Clinically, SLC27A1 overexpression in melanomas facilitates adipocyte-derived lipid uptake, promoting tumor proliferation and invasion; pharmacologic FATP inhibition reduces melanoma growth 4. In diabetic cardiomyopathy, altered SLC27A1 expression is implicated in metabolic disturbances and cardiac dysfunction 5. The gene maps to chromosome 19.1, a region associated with lipid metabolism disorders 1.